Psihologia Dezvoltarii Umane Ana Muntean.pdf
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Psihologia dezvoltarii, - Răzvan Păducan:
Date despre program: 28.01.2007 - Bucureşti:. Departamentul de Psihologie dezvoltarii Umane.
Psihologia dezvoltarii, Departamentul de Psihologie dezvoltarii umane:. antonina.com. “Psihologia dezvoltarii umane»,. Download Psihologia Dezvoltarii Umane. Psihologia Dezvoltarii Umane Ana Muntean Pdf 25.Induction of sterol response element binding protein-1 and mitochondrial glycerophosphate dehydrogenase mRNAs in C6 glioma cells by phorbol ester and mezerein.
Sterol regulatory element binding proteins (SREBPs) are synthesized as precursor proteins that are post-translationally processed to form mature forms. SREBP-1 (pre-SREBP-1) precursor is the first described precursor to form a mature active form of SREBP-1. SREBP-1 is induced by cellular sterol depletion. The regulation of SREBP-1 expression was investigated in C6 glioma cells using SREBP-1 promoter-luciferase reporter constructs. SREBP-1 promoter activity was induced by PMA at concentrations of >10 ng/ml. Both SREBP-1 mRNA and protein were induced by PMA. The present study was undertaken to determine whether SREBP-1 induction by PMA is mediated via protein kinase C. Treatment with the protein kinase C inhibitors, 1-O-tetradecanoyl phorbol-13-acetate, 1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride, and calphostin C significantly inhibited PMA-mediated SREBP-1 promoter activation. PMA also induced mitochondrial glycerophosphate dehydrogenase (mGPD) mRNA and protein expression in C6 glioma cells, a gene regulated by sterol. To determine whether the effects of PMA on SREBP-1 and mGPD were mediated through protein kinase C, C6 cells were treated with PMA in the presence of the 0b46394aab
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